Metformin in the treatment of patients with non-alcoholic steatohepatitis.

  title={Metformin in the treatment of patients with non-alcoholic steatohepatitis.},
  author={Ahmet Uygun and Abdurrahman Kadayifci and Ahmet Turan Isik and Taner Ozgurtas and Serol Deveci and Ali Tuzun and Zeki Yeşilova and M Gulsen and Kemal Dağalp},
  journal={Alimentary pharmacology & therapeutics},
  volume={19 5},
BACKGROUND Increased insulin resistance is the major pathogenic mechanism in the development of non-alcoholic steatohepatitis. AIM To investigate the therapeutic effect of metformin, a well-known insulin-sensitizing agent, in the treatment of non-alcoholic steatohepatitis. METHODS Thirty-six patients with non-alcoholic steatohepatitis were randomized into two groups. The first group was given lipid and calorie-restricted dietary treatment alone, and the second group was given metformin 850… CONTINUE READING


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