Metformin in polycystic ovary syndrome

  title={Metformin in polycystic ovary syndrome},
  author={Evanthia Diamanti-Kandarakis and Frangiskos N Economou and Sotiria Palimeri and Charikleia D Christakou},
  journal={Annals of the New York Academy of Sciences},
Polycystic ovary syndrome (PCOS) affects 6.6–6.8% of women in reproductive age. Insulin resistance and hyperinsulinemia play a critical role in the pathogenesis of PCOS and are associated with a high risk for type 2 diabetes mellitus and cardiometabolic abnormalities. Metformin has been introduced as a therapeutic option in PCOS, targeting of cardiometabolic and reproductive abnormalities on the basis of its action on the reduction of glucose levels and the attenuation of insulin resistance… 

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Polycystic ovary syndrome is one of the most common endocrine disorders affecting females and various regimens have been developed for the treatment ranging from lifestyle modification to clomiphene to IVF with no consensus.


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