Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures.

@article{abuzek2010MetforminHA,
  title={Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures.},
  author={Krzysztof Łabuzek and Sebastian Liber and Bożena Gabryel and Bogusław Okopień},
  journal={Pharmacological reports : PR},
  year={2010},
  volume={62 5},
  pages={827-48}
}
The results of recent studies suggest that metformin, in addition to its efficacy in treating type 2 diabetes, may also have therapeutic potential for the treatment of neuroinflammatory diseases in which reactive microglia play an essential role. However, the molecular mechanisms by which metformin exerts its anti-inflammatory effects remain largely unknown. Adenosine-monophosphate-activated protein kinase (AMPK) activation is the most well-known mechanism of metformin action; however, some of… CONTINUE READING
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