Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder.

@article{Jarskog2013MetforminFW,
  title={Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder.},
  author={Lars Fredrik Jarskog and Robert M. Hamer and Diane J. Catellier and Dawn D Stewart and Lisa M Lavange and Neepa Ray and Lauren H Golden and Jeffrey A. Lieberman and T. Scott Stroup},
  journal={The American journal of psychiatry},
  year={2013},
  volume={170 9},
  pages={1032-40}
}
OBJECTIVE The purpose of this study was to determine whether metformin promotes weight loss in overweight outpatients with chronic schizophrenia or schizoaffective disorder. METHOD In a double-blind study, 148 clinically stable, overweight (body mass index [BMI] ≥27) outpatients with chronic schizophrenia or schizoaffective disorder were randomly assigned to receive 16 weeks of metformin or placebo. Metformin was titrated up to 1,000 mg twice daily, as tolerated. All patients continued to… CONTINUE READING
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