Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis.

  title={Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis.},
  author={Samir Kumar Praharaj and Amlan Kusum Jana and Nishant Goyal and Vinod Kumar Sinha},
  journal={British journal of clinical pharmacology},
  volume={71 3},
Olanzapine is an atypical antipsychotic that is useful in schizophrenia and bipolar affective disorder, but its use is associated with troublesome weight gain and metabolic syndrome. A variety of pharmacological agents has been studied in the efforts to reverse weight gain induced by olanzapine, but current evidence is insufficient to support any particular pharmacological approach. We conducted a systematic review and meta-analysis of randomized controlled trials of metformin for the treatment… CONTINUE READING
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