Metformin enhances the response to radiotherapy in diabetic patients with rectal cancer

  title={Metformin enhances the response to radiotherapy in diabetic patients with rectal cancer},
  author={Bo Young Oh and Yoon Ah Park and Jung Huh and Yong B. Cho and Seong Hyeon Yun and Woo Yong Lee and Hee Chul Park and Doo Ho Choi and Yong Seog Park and Hee - Cheol Ezra Kim},
  journal={Journal of Cancer Research and Clinical Oncology},
Metformin may have anticancer effects and could improve response to radiotherapy in several malignancies. We aimed to investigate the effect of metformin on response to radiotherapy in rectal cancer. A total of 543 rectal cancer patients who were treated with neoadjuvant chemoradiotherapy followed by radical surgery from January 2007 to December 2011 were reviewed. Patients were divided into three groups: diabetics taking metformin (n = 42), diabetics not taking metformin (n = 29), and non… CONTINUE READING


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