Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress.

@article{Roesen2006MetforminDT,
  title={Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress.},
  author={Peter Roesen and Nicolas F. Wiernsperger},
  journal={Diabetes/metabolism research and reviews},
  year={2006},
  volume={22 4},
  pages={323-30}
}
BACKGROUND AND AIM This study was undertaken to test the hypothesis that hyperglycaemia induces the generation of reactive oxygen species (ROS) by mitochondria and that the oxidative stress thereby exerted is diminished by treatment with metformin. As a parameter of mitochondrial ROS formation, the activity of mitochondrial aconitase activity was determined… CONTINUE READING