Metformin decreases the incidence of ovarian hyperstimulation syndrome: an experimental study

  title={Metformin decreases the incidence of ovarian hyperstimulation syndrome: an experimental study},
  author={Evelin Mariel Elia and Ramiro Quintana and Carlos Carrere and Mar{\'i}a Victoria Bazzano and Gast{\'o}n J Rey-Valzacchi and Dante Agust{\'i}n Paz and Mar{\'i}a Carolina Pustovrh},
  booktitle={Journal of ovarian research},
BACKGROUND In assisted reproduction cycles, gonadotropins are administered to obtain a greater number of oocytes. A majority of patients do not have an adverse response; however, approximately 3-6% develop ovarian hyperstimulation syndrome (OHSS). Metformin reduces the risk of OHSS but little is known about the possible effects and mechanisms of action involved. OBJECTIVE To evaluate whether metformin attenuates some of the ovarian adverse effects caused by OHSS and to study the mechanisms… CONTINUE READING


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