Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance.

@article{Tan2008MetforminDT,
  title={Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance.},
  author={Bee Kang Tan and Dennis Heutling and Jing Chen and Syed Farhatullah and Raghu Adya and Stephen D. Keay and Christopher R. J. Kennedy and Hendrik Lehnert and Harpal Randeva},
  journal={Diabetes},
  year={2008},
  volume={57 6},
  pages={1501-7}
}
OBJECTIVE Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Vaspin (visceral adipose tissue-derived serine protease inhibitor) levels increase with hyperinsulinemia and obesity. Currently, no data exists on vaspin in PCOS women. We therefore assessed mRNA and protein levels of vaspin, including circulating vaspin, from subcutaneous and omental adipose tissue of PCOS women and matched control subjects. Ex vivo regulation of adipose tissue vaspin and the effects… CONTINUE READING
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