Metformin decreases meal size and number and increases c-Fos expression in the nucleus tractus solitarius of obese mice.

@article{Kim2013MetforminDM,
  title={Metformin decreases meal size and number and increases c-Fos expression in the nucleus tractus solitarius of obese mice.},
  author={Hyun-Ju Kim and Xian-hua Zhang and Eun-Young Park and Kyung-ho Shin and S Choi and Boe-Gwun Chun and D. Kim},
  journal={Physiology & behavior},
  year={2013},
  volume={110-111},
  pages={213-20}
}
Metformin is widely used to treat obese diabetics because of its beneficial effects on body weight, energy intake, and glucose regulation. However, it has not been investigated how oral metformin affects meal patterns, or whether the reduced food intake is associated with neuronal activation in the hindbrain. Accordingly, we investigated how orally administered metformin (150 or 300 mg/kg daily for 4 or 7 days) reduces body weight in obese mice on a high-fat diet by continuously measuring meal… CONTINUE READING