Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.

Abstract

Metformin (dimethylbiguanide) has been used for more than 30 years as an antihyperglycemic agent in the treatment of diabetes mellitus, but its effect on gluconeogenesis is still controversial. In isolated hepatocytes from fasted rats, a significant inhibition of glucose production from lactate/pyruvate (10:1, mol/mol), fructose, alanine or glutamine… (More)

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@article{Argaud1993MetforminDG, title={Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.}, author={Deborah Argaud and H. Roth and Nicolas F Wiernsperger and Xavier Leverve}, journal={European journal of biochemistry}, year={1993}, volume={213 3}, pages={1341-8} }