Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients.

@article{Carvajal2013MetforminAT,
  title={Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients.},
  author={Rodrigo Carvajal and Carlos Rosas and Karla Kohan and Fernando Gabler and David Vantman and Carmen Carrascosa Romero and Margarita Vega},
  journal={Human reproduction},
  year={2013},
  volume={28 8},
  pages={2235-44}
}
STUDY QUESTION Does treatment with the insulin sensitizer metformin modify the levels and activation of proteins related to the expression of the insulin-dependent glucose transporter (GLUT4), such as adenosine monophosphate-activated protein kinase (AMPK) and myocyte enhancer factor 2A (MEF2A), in endometria from hyperinsulinemic hyperandrogenemic polycystic ovary syndrome (PCOS h-Ins) patients? SUMMARY ANSWER In PCOS h-Ins patients, metformin increases endometrial levels of GLUT4 mRNA and… CONTINUE READING
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