Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth.

  title={Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth.},
  author={Carolyn Algire and Mahvash Zakikhani and M Blouin and Jian Shuai and Michael N. Pollak},
  journal={Endocrine-related cancer},
  volume={15 3},
We investigated the effects of metformin on the growth of lewis lung LLC1 carcinoma in C57BL/6J mice provided with either a control diet or a high-energy diet, previously reported to lead to weight gain and systemic insulin resistance with hyperinsulinemia. Forty-eight male mice were randomized into four groups: control diet, control diet+metformin, high-energy diet, or high-energy diet+metformin. Following 8 weeks on the experimental diets, selected groups received metformin in their drinking… CONTINUE READING


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