Metformin attenuates lung fibrosis development via NOX4 suppression


BACKGROUND Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has been proposed to be involved in the… (More)
DOI: 10.1186/s12931-016-0420-x


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