Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α.

@article{Chen2018MetforminAA,
  title={Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α.},
  author={Ruifei Chen and Yenan Feng and Jimin Wu and Yao Ying Song and Hao Li and Qiang Shen and Dan Li and Jianshu Zhang and Zhizhen Lu and Han Xiao and Youyi Zhang},
  journal={British journal of pharmacology},
  year={2018},
  volume={175 8},
  pages={
          1217-1229
        }
}
BACKGROUND AND PURPOSE Metformin, a small molecule, antihyperglycaemic agent, is a well-known activator of AMP-activated protein kinase (AMPK) and protects against cardiac fibrosis. However, the underlying mechanisms remain elusive. TGFβ1 is a key cytokine mediating cardiac fibrosis. Here, we investigated the effects of metformin on TGFβ1 production induced by angiotensin II (AngII) and the underlying mechanisms. EXPERIMENTAL APPROACH Wild-type and AMPKα2-/- C57BL/6 mice were injected s.c… CONTINUE READING
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