Metformin attenuate PTZ-induced apoptotic neurodegeneration in human cortical neuronal cells

@inproceedings{Bibi2017MetforminAP,
  title={Metformin attenuate PTZ-induced apoptotic neurodegeneration in human cortical neuronal cells},
  author={Fehmida Bibi and Ikram Ullah and Myeong Ok Kim and Muhammad Imran Naseer},
  booktitle={Pakistan journal of medical sciences},
  year={2017}
}
OBJECTIVE Seizures are one of the neurodegenerative disorders of human being. Metformin has antioxidant properties and commonly used as an oral antidiabetic drug. The current study was aimed to observe the neuroprotective effect of metformin against PTZ-induced apoptotic neurodegeneration in human cortical neuronal cell culture. METHODS To observe that exposure of pentylenetetrazol (PTZ) at the dose of (30mM) for 30 minutes induced neuronal cell death by activation of caspase-3 in human… CONTINUE READING