Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.

@article{Laar2011MetforminAL,
  title={Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.},
  author={Inge R F van Berlo-van de Laar and C. G. Vermeij and Cornelius J Doorenbos},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2011},
  volume={36 3},
  pages={376-82}
}
WHAT IS KNOWN AND OBJECTIVE The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years. In clinical practice, 22-94% of patients using metformin have contraindications to metformin, so the incidence of MALA may be higher than reported. AIM OF THE STUDY To estimate the incidence of MALA in type 2 DM patients by means of metformin serum concentration measurements and investigate the correlation of metformin serum… CONTINUE READING

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