Metformin as adjuvant therapy to IVF in women with PCOS: when is intention-to-treat unintentional?

More than 15 years have passed since metformin was hailed as a possible treatment for infertility in women with polycystic ovary syndrome (PCOS) (Velazquez et al., 1994). Though a recent Cochrane Systematic review examining metformin for ovulation induction concludes that ‘the use of metformin in improving reproductive outcomes in women with PCOS appears to… (More)