Metformin and the gastrointestinal tract

@inproceedings{McCreight2015MetforminAT,
  title={Metformin and the gastrointestinal tract},
  author={Laura J McCreight and Clifford J Bailey and Ewan R Pearson},
  booktitle={Diabetologia},
  year={2015}
}
Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood. Although the liver is recognised as a major site of metformin pharmacodynamics, recent evidence also implicates the gut as an important site of action. Metformin has a number of actions within the gut. It increases intestinal glucose uptake and lactate production… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 70 CITATIONS, ESTIMATED 42% COVERAGE

The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus

  • Journal of diabetes research
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2016
2019

CITATION STATISTICS

  • 2 Highly Influenced Citations

  • Averaged 21 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 86 REFERENCES

Pharmacogenetic variation and metformin response.

  • Current drug metabolism
  • 2013
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

GLUT2 Accumulation in Enterocyte Apical and Intracellular Membranes

Amal Ait-Omar, Milena Monteiro-Sepulveda, +15 authors Edith Brot-Laroche
  • Diabetes
  • 2011
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.

  • Biochemical and biophysical research communications
  • 2002
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…