Metformin and insulin receptors.

  title={Metformin and insulin receptors.},
  author={Riccardo Vigneri and Damiano Gullo and Vincenzo Pezzino},
  journal={Diabetes care},
  volume={7 Suppl 1},
We evaluated the effect of metformin (N,N-dimethylbiguanide), a biguanide known to be less toxic than phenformin, on insulin binding to its receptors, both in vitro and in vivo. Specific 125I-insulin binding to cultured IM-9 human lymphocytes and MCF-7 human breast cancer cells was determined after preincubation with metformin. Specific 125I-insulin binding… CONTINUE READING