Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.

@article{Burt2016MetforminAC,
  title={Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.},
  author={Howard J. Burt and Sibylle Neuhoff and Lisa M Almond and Lu Gaohua and Matthew D. Harwood and Masoud Jamei and Amin Rostami-Hodjegan and Geoffrey T. Tucker and Karen Rowland-Yeo},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2016},
  volume={88},
  pages={70-82}
}
Metformin is used as a probe for OCT2 mediated transport when investigating possible DDIs with new chemical entities. The aim of the current study was to investigate the ability of physiologically-based pharmacokinetic (PBPK) models to simulate the effects of OCT and MATE inhibition by cimetidine on metformin kinetics. PBPK models were developed… CONTINUE READING