Metformin and cancer: new applications for an old drug.

  title={Metformin and cancer: new applications for an old drug.},
  author={Taxiarchis Kourelis and Robert D. Siegel},
  journal={Medical oncology},
  volume={29 2},
Metformin, one of most widely prescribed oral hypoglycemic agents, has recently received increased attention because of its potential antitumorigenic effects that are thought to be independent of its hypoglycemic effects. Several potential mechanisms have been suggested for the ability of metformin to suppress cancer growth in vitro and vivo: (1) activation of LKB1/AMPK pathway, (2) induction of cell cycle arrest and/or apoptosis, (3) inhibition of protein synthesis, (4) reduction in… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 108 extracted citations


Publications referenced by this paper.
Showing 1-10 of 101 references

B(12), and enhanced breast cancer response to chemotherapy

  • A Garcia, G Tisman, Metformin
  • J Clin Oncol
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…