Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells

  title={Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells},
  author={Tarek H. Mouhieddine and Amaly Nokkari and Muhieddine M. Itani and Farah Chamaa and Hisham F Bahmad and Alissar Monzer and Rabih El-Merahbi and Georges E Daoud and Assaad Eid and Firas H. Kobeissy and Wassim Abou-Kheir},
  booktitle={Front. Neurosci.},
BACKGROUND Gliomas and neuroblastomas pose a great health burden worldwide with a poor and moderate prognosis, respectively. Many studies have tried to find effective treatments for these primary malignant brain tumors. Of interest, the AMP-activated protein kinase (AMPK) pathway was found to be associated with tumorigenesis and tumor survival, leading to many studies on AMPK drugs, especially Metformin, and their potential role as anti-cancer treatments. Cancer stem cells (CSCs) are a small… CONTINUE READING
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Glioblastoma stem cells: a new target for metformin and arsenic trioxide.

Journal of biological regulators and homeostatic agents • 2014
View 15 Excerpts
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J . Biol . Chem . • 2015
View 1 Excerpt

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