Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome.

@article{Genazzani2004MetforminAM,
  title={Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome.},
  author={Alessandro David Genazzani and Cesare Battaglia and Barbara Malavasi and Claudia Strucchi and Francesca Tortolani and Ombretta Gamba},
  journal={Fertility and sterility},
  year={2004},
  volume={81 1},
  pages={114-9}
}
OBJECTIVE To evaluate the effects of metformin administration on spontaneous LH episodic release in a group of nonobese polycystic ovary (PCOS) patients. DESIGN Controlled clinical study. SETTING PCOS patients in a clinical research environment. PATIENT(S) Twenty nonobese PCOS patients were enrolled after informed consent. INTERVENTION(S) All patients underwent hormonal evaluations and a pulsatility study (sampling every 10 minutes for 4 hours) before and at the sixth month of therapy… CONTINUE READING