Metformin accumulation: Lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy

@article{Vecchio2014MetforminAL,
  title={Metformin accumulation: Lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy},
  author={Sarah Vecchio and Andrea Giampreti and Valeria Margherita Petrolini and Davide Lonati and Alessandro Protti and Pietro Papa and Carla Rognoni and Antonella Valli and Loretta Rocchi and Laura Rolandi and Luigi Manzo and Carlo Alessandro Locatelli},
  journal={Clinical Toxicology},
  year={2014},
  volume={52},
  pages={129 - 135}
}
Abstract Objective. The relationship between metformin accumulation and lactate increase is still debated. This observational case series aims to evaluate the correlation of metformin plasma levels with the pH, lactate and creatinine levels, and with the mortality rate in selected patients with metformin accumulation confirmed through metformin plasma concentration detection at hospital admission. Material and methods. All cases of lactic acidosis (pH, ≤ 7.35; arterial lactate, ≥ 5 mmol/L… 

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