Metformin Use During Treatment of Potentially Curable Esophageal Cancer Patients is not Associated with Better Outcomes

@article{Spierings2015MetforminUD,
  title={Metformin Use During Treatment of Potentially Curable Esophageal Cancer Patients is not Associated with Better Outcomes},
  author={L. E. A. M. M. Spierings and PhD S. M. Lagarde and Martijn G. H. van Oijen and PhD S. S. Gisbertz and PhD J. W. Wilmink and PhD M. C. C. M. Hulshof and PhD S. L. Meijer and Martinus C J Anderegg and PhD M. I. van Berge Henegouwen and PhD H. W. M. van Laarhoven},
  journal={Annals of Surgical Oncology},
  year={2015},
  volume={22},
  pages={766-771}
}
Metformin use has been associated with a dose-dependent increased response to neoadjuvant chemo(radio)therapy in esophageal cancer patients. However, no association between metformin use and overall survival has been reported yet. The purpose of our study was to investigate the effect of metformin use on pathological response as well as overall and disease-free survival in patients with resectable esophageal cancer. Between March 1994 and September 2013, all patients undergoing an esophagectomy… CONTINUE READING

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