Metformin Decelerates Aging and Development of Mammary Tumors in HER-2/neu Transgenic Mice

  title={Metformin Decelerates Aging and Development of Mammary Tumors in HER-2/neu Transgenic Mice},
  author={Vladimir N. Anisimov and Peter A. Egormin and L. M. Bershtein and M. A. Zabezhinskii and Tatiana S. Piskunova and Irina G. Popovich and Anna V. Semenchenko},
  journal={Bulletin of Experimental Biology and Medicine},
Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age of 2 months until natural death. Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gain. Mean life span of mice increased by 8% (p<0.05), in 10% long-living mice it was prolonged by 13.1%, and the maximum life span was prolonged by 1 month under the effect of metformin in comparison… CONTINUE READING
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Traditions, State of the Art, Prospects [in Russian

  • L. M. Bershtein, Oncoendocrinology
  • St. Petersburg
  • 2004
3 Excerpts

Effect of metformin on life span and development of mammary adenocarcinoma in HER-2/neu transgenic female mice. a) dynamics of mouse survival; b) dynamics of development of new tumors

  • V. N. Anisimov, P. A. Egormin
  • J. Gerontol. Biol. Sci.,
  • 2001
1 Excerpt

Computation Methods of Analysis and Recognition of Pathological Processes [in Russian

  • E. V. Gubler
  • 1978
1 Excerpt

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