Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

@inproceedings{Lachmandas2019MetforminAH,
  title={Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects},
  author={E. L. Lachmandas and Clare Eckold and Julia Boehme and Valerie A C M Koeken and Mardiana Binte Marzuki and Bastiaan A. Blok and Rob J W Arts and Jinmiao Chen and Karen Wei Weng Teng and Jacqueline M Ratter and Elise J Smolders and Corina Van den Heuvel and Rinke Stienstra and Hazel M Dockrell and Evan William Newell and Mihai G. Netea and Amit Singhal and Jacqueline Margaret Cliff and Reinout van Crevel},
  booktitle={The Journal of infectious diseases},
  year={2019}
}
BACKGROUND Metformin, the most widely administered diabetes drug, has been proposed as a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its effects on human host responses to Mycobacterium tuberculosis. METHODS We investigated in vitro and in vivo effects of metformin in humans. RESULTS Metformin added to peripheral blood mononuclear cells from healthy volunteers enhanced in vitro cellular metabolism while inhibiting the mammalian target of rapamycin… CONTINUE READING
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