Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence

@inproceedings{Hooten2016MetforminmediatedII,
  title={Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence},
  author={Nicole Noren Hooten and Alejandro Martin‐Montalvo and Douglas F Dluzen and Yonqing Zhang and Michel Bernier and Alan B. Zonderman and Kevin G. Becker and Myriam Gorospe and Rafael de Cabo and Michele K Evans},
  booktitle={Aging cell},
  year={2016}
}
Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer manifestations of age-related chronic disease. However, the molecular mechanisms underlying this phenotype are unknown. Here, we show that metformin treatment increases the levels of the microRNA-processing protein DICER1 in mice and in humans with diabetes mellitus. Our results indicate that metformin upregulates… CONTINUE READING
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