Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence

  title={Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence},
  author={Nicole Noren Hooten and Alejandro Martin‐Montalvo and Douglas F Dluzen and Yonqing Zhang and Michel Bernier and Alan B. Zonderman and Kevin G. Becker and Myriam Gorospe and Rafael de Cabo and Michele K Evans},
  booktitle={Aging cell},
Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer manifestations of age-related chronic disease. However, the molecular mechanisms underlying this phenotype are unknown. Here, we show that metformin treatment increases the levels of the microRNA-processing protein DICER1 in mice and in humans with diabetes mellitus. Our results indicate that metformin upregulates… CONTINUE READING
Highly Cited
This paper has 29 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 15 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Regulating microRNA expression: at the heart of diabetes mellitus and the mitochondrion.

American journal of physiology. Heart and circulatory physiology • 2018
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 11 references

miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 2 Excerpts
Highly Influenced

An E2F/miR-20a autoregulatory feedback loop.

The Journal of biological chemistry • 2007
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…