Metformin: historical overview

@article{Bailey2017MetforminHO,
  title={Metformin: historical overview},
  author={Clifford J Bailey},
  journal={Diabetologia},
  year={2017},
  volume={60},
  pages={1566-1576}
}
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also known as goat’s rue), a traditional herbal medicine in Europe, found to be rich in guanidine, which, in 1918, was shown to lower blood glucose. Guanidine derivatives, including metformin, were synthesised and some (not metformin) were used to treat diabetes in the 1920s and 1930s but were discontinued due to toxicity and… CONTINUE READING