Metformin: New Preparations and Nonglycemic Benefits

@article{Fujita2017MetforminNP,
  title={Metformin: New Preparations and Nonglycemic Benefits},
  author={Yoshihito Fujita and Nobuya Inagaki},
  journal={Current Diabetes Reports},
  year={2017},
  volume={17},
  pages={1-10}
}
Metformin has been widely used for over 5 decades. New preparations have been developed for possible enhancement of efficiency, tolerability, and pleiotropic nonglycemic effects. Extended-release metformin has contributed to adherence and improved gastrointestinal tolerability. Delayed-release metformin acts in the lower gastrointestinal tract and exerts glucose-lowering effects at lower plasma metformin levels, which might suggest use of this biguanide in patients with chronic kidney disease… 
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