Metformin: An Update

@article{Kirpichnikov2002MetforminAU,
  title={Metformin: An Update},
  author={Dmitri Kirpichnikov and Samy I McFarlane and James R. Sowers},
  journal={Annals of Internal Medicine},
  year={2002},
  volume={137},
  pages={25-33}
}
Insulin resistance contributes greatly to development of cardiovascular disease in patients with the metabolic syndrome and its extreme presentation, type 2 diabetes mellitus. Therefore, treatment with an insulin-sensitizing agent, such as metformin, in patients with type 2 diabetes mellitus may correct several of the primary pathophysiologic abnormalities of the metabolic syndrome. In diabetic patients, metformin appears to provide cardiovascular protection that cannot be attributed only to… 

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