Metformin: 50 years old, fit as a fiddle, and indispensable for its pivotal role in type 2 diabetes management.

  title={Metformin: 50 years old, fit as a fiddle, and indispensable for its pivotal role in type 2 diabetes management.},
  author={Serge Halimi},
  journal={Diabetes & metabolism},
  volume={32 6},
iguanides are by-products of guanidine, an active substance extracted from Galega officinalis (Goat’s rue), a plant used as early as the Middle Ages for its antidiabetic virtues. The glucose-lowering effect of guanidine was discovered in 1918. Several derivates were extracted, many of which turned out to be toxic and therefore were not produced or were withdrawn from the market, as was phenformin in 1976. The career of metformin dates back to 1957 along with the only other oral antidiabetics… CONTINUE READING
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