Metformin, Microbiome and Protection Against Colorectal Cancer

@article{Jones2020MetforminMA,
  title={Metformin, Microbiome and Protection Against Colorectal Cancer},
  author={Georgina R. Jones and Mark P. Molloy},
  journal={Digestive Diseases and Sciences},
  year={2020},
  pages={1-6}
}
Metformin is widely used as a firstline therapy to improve insulin sensitivity in type 2 diabetes mellitus (T2DM) patients. This is achieved primarily through regulating AMP-activated protein kinase (AMPK)-dependent pathways leading to reduced hepatic gluconeogenesis and improved muscular uptake of glucose. Epidemiological studies first recognized a relationship with metformin use in T2DM patients and reduced colorectal cancer (CRC) risk. Thereafter, metformin has gained wide attention as a… Expand

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References

SHOWING 1-10 OF 63 REFERENCES
Metformin as an Anticancer Agent.
TLDR
Recent advances in elucidating the molecular mechanisms that are relevant for metformin use in cancer treatment are discussed. Expand
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
TLDR
It is concluded that metformin acts in part through a B. fragilis–GUDCA–intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia, and improves the metabolic health of humans and mice. Expand
Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect.
  • Y. Saisho
  • Medicine
  • Endocrine, metabolic & immune disorders drug targets
  • 2015
TLDR
The basic and clinical evidence of the anti-inflammatory action of metformin is summarized and its clinical implication is discussed. Expand
Metformin—mode of action and clinical implications for diabetes and cancer
TLDR
The updated understanding of the antigluconeogenic action of met formin in the liver and the implications of the discoveries of metformin targets for the treatment of diabetes mellitus and cancer are discussed. Expand
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
TLDR
It is shown that metformin affected pathways with common biological functions in species from two different phyla, and many of the met formin-regulated genes in these species encoded metalloproteins or metal transporters, which provides support for the notion that altered gut microbiota mediates some of metformIn's antidiabetic effects. Expand
Metformin and reduced risk of cancer in diabetic patients
TLDR
It is hypothesised that metformin use in patients with type 2 diabetes may reduce their risk of cancer and tested this hypothesis using record linkage databases developed in Tayside, Scotland: a diabetes clinical information system (DARTS) and a database of dispensed prescriptions (MEMO). Expand
The mechanisms of action of metformin
TLDR
Physiologically, metformin has been shown to reduce hepatic glucose production, yet not all of its effects can be explained by this mechanism and there is increasing evidence of a key role for the gut. Expand
Metformin for Prevention and Treatment of Colon Cancer: A Reappraisal of Experimental and Clinical Data.
TLDR
The available data on the capacity of antidiabetic biguanide drugs to prevent colorectal carcinogenesis and growth in vitro and in vivo in experimental models and clinical observations are presented. Expand
Diet, microorganisms and their metabolites, and colon cancer
  • S. O'keefe
  • Biology, Medicine
  • Nature Reviews Gastroenterology &Hepatology
  • 2016
TLDR
The mechanisms behind microbial metabolite effects, which could be modified by diet to achieve the objective of preventing colorectal cancer in Western societies are discussed. Expand
Metformin suppresses azoxymethane‐induced colorectal aberrant crypt foci by activating AMP‐activated protein kinase
TLDR
Colorectal carcinogenesis in chemical carcinogen‐induced models is examined and metformin suppresses colonic epithelial proliferation via the inhibition of the mTOR pathway through the activation of AMPK. Expand
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