• Corpus ID: 9245663

Metered dose pressurized aerosols and the ozone layer.

@article{Newman1990MeteredDP,
  title={Metered dose pressurized aerosols and the ozone layer.},
  author={Stephen P. Newman},
  journal={The European respiratory journal},
  year={1990},
  volume={3 5},
  pages={
          495-7
        }
}
  • S. Newman
  • Published 1 May 1990
  • Chemistry
  • The European respiratory journal
The term "aerosol" has a precise scientific definition as liquid or solid particles suspended in air [1], but has in the last few decades acquired a new non-scientific meaning as a self-contained, sprayable product in which the propellant force is supplied by liquefied gas [2]. The propellants used in these aerosol canisters are of several types, namely: a) chlorofluorocarbons (CFCs); b) hydrocarbons, such as propane and isobutane; c) mixtures of CFCs and hydrocarbons, which are used in many… 
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This trial shows significantly greater efficiency of aerosol deposition to the lung in ventilator-dependent patients when using an MDI plus aerosol holding chamber than when using a jet nebulizer.
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Results suggest that both the distribution of drug and the clinical effect of terbutaline sulphate delivered from Turbuhaler are similar to those from a pressurised metered dose inhaler (MDI).
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Inhaled frusemide may serve as a functional antagonist against a smooth muscle spasmogen, such as methacholine, possibly by augmenting prostanoid generation and its more potent activity against AMP and other bronchoconstrictor stimuli suggests an additional action on mast cell functions possibly at the level of the Ca++/Mg(++)-ATPase.
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