Metazoan cell biology of the HOPS tethering complex.

  title={Metazoan cell biology of the HOPS tethering complex.},
  author={Stephanie A Zlatic and Karine Tornieri and Steven W L'Hernault and Victor Faundez},
  journal={Cellular logistics},
  volume={1 3},
Membrane fusion with vacuoles, the lysosome equivalent of the yeast Saccharomyces cerevisiae, is among the best understood membrane fusion events. Our precise understanding of this fusion machinery stems from powerful genetics and elegant in vitro reconstitution assays. Central to vacuolar membrane fusion is the multi-subunit tether the HO motypic fusion and Protein Sorting (HOPS) complex, a complex of proteins that organizes other necessary components of the fusion machinery. We lack a… CONTINUE READING

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