Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance

  title={Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance},
  author={V. Seitan and P. Banks and S. Laval and Nazia A Majid and D. Dorsett and Amer A Rana and J. Smith and A. Bateman and Sanja Krpic and Arnd Hostert and R. A. Rollins and H. Erdjument-Bromage and P. Tempst and C. B{\'e}nard and S. Hekimi and S. Newbury and T. Strachan},
  journal={PLoS Biology},
  • V. Seitan, P. Banks, +14 authors T. Strachan
  • Published 2006
  • Biology, Medicine
  • PLoS Biology
  • Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating sister chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in… CONTINUE READING
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