Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance

@article{Seitan2006MetazoanSH,
  title={Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance},
  author={V. Seitan and P. Banks and S. Laval and Nazia A Majid and D. Dorsett and Amer A Rana and J. Smith and A. Bateman and Sanja Krpic and Arnd Hostert and R. A. Rollins and H. Erdjument-Bromage and P. Tempst and C. B{\'e}nard and S. Hekimi and S. Newbury and T. Strachan},
  journal={PLoS Biology},
  year={2006},
  volume={4}
}
  • V. Seitan, P. Banks, +14 authors T. Strachan
  • Published 2006
  • Biology, Medicine
  • PLoS Biology
  • Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating sister chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in… CONTINUE READING
    110 Citations
    The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis
    • 7
    • Highly Influenced
    • PDF
    Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase
    • 18
    • Highly Influenced
    Cohesin, gene expression and development: Lessons from Drosophila
    • D. Dorsett
    • Biology, Medicine
    • Chromosome Research
    • 2009
    • 74
    Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved.
    • 87
    Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells
    • 71
    Cohesin loading and sliding
    • 67
    • PDF
    Cohesin gene defects may impair sister chromatid alignment and genome stability in Arabidopsis thaliana
    • 42
    Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome
    • 232

    References

    SHOWING 1-10 OF 73 REFERENCES
    Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21.
    • 41
    • Highly Influential
    Scc2 Couples Replication Licensing to Sister Chromatid Cohesion in Xenopus Egg Extracts
    • 191
    The Coprinus cinereus adherin Rad9 functions in Mre11-dependent DNA repair, meiotic sister-chromatid cohesion, and meiotic homolog pairing
    • 20
    • PDF
    HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions.
    • 292
    • PDF
    Chromosome cohesion is regulated by a clock gene paralogue TIM-1
    • 154
    • PDF