Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells.

@article{Ringel2002MetastinRI,
  title={Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells.},
  author={Matthew D. Ringel and Elena Hardy and Victor J Bernet and H B Bubba Burch and Frank Schuppert and Kenneth D. Burman and Motoyasu Saji},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 5},
  pages={
          2399
        }
}
The development of distant metastasis is the most important predictor of death from thyroid cancer. KiSS-1 is a recently cloned human metastasis suppressor gene whose product, metastin, was recently identified as the endogenous agonist for a novel Gq/11 coupled receptor (metastin receptor). The expression and functional consequences of metastin and the metastin receptor have not been evaluated in thyroid cancer. We measured metastin and metastin receptor mRNA levels in 10 FCs and 13 papillary… CONTINUE READING
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