Metastin and its G protein-coupled receptor, GPR54: Critical pathway modulating GnRH secretion

@article{Seminara2005MetastinAI,
  title={Metastin and its G protein-coupled receptor, GPR54: Critical pathway modulating GnRH secretion},
  author={Stephanie Beth Seminara},
  journal={Frontiers in Neuroendocrinology},
  year={2005},
  volume={26},
  pages={131-138}
}
Photoperiod, food availability, temperature, stress, and hormonal cues are some of the varied signals used by mammalian species to activate or suppress their timing of sexual maturation. All ultimately converge upon gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus. Through its stimulation of LH and FSH from the pituitary, GnRH represents a critical step in the reproductive cascade. While few dispute this central role of GnRH, little is understood of the mechanisms… CONTINUE READING
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