Metastatic vulvar Paget's disease responding to combination chemotherapy: case report.

@article{Yokoyama1990MetastaticVP,
  title={Metastatic vulvar Paget's disease responding to combination chemotherapy: case report.},
  author={Yoshihito Yokoyama and Megumi Mabuchi and Isao Kawabata and Kenji Niwa and Kontoku Shimokawa and Teruhiko Tamaya},
  journal={Japanese journal of clinical oncology},
  year={1990},
  volume={20 4},
  pages={426-30}
}
No effective chemotherapy for advanced extramammary Paget's disease has yet been established. A case of vulvar Paget's disease with systemic metastases was treated with a mitomycin C, vincristine and cisplatin combination chemotherapy, by which the vulvar lesion and serum CEA were clearly decreased. After surgery and 5-fluorouracil treatment, a similar combination chemotherapeutic regimen was administered to treat a recurrence, however, the lesions became resistant.