Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma.

@article{DArrigo2005MetastaticTP,
  title={Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma.},
  author={Antonello D'Arrigo and Claudio Belluco and Alessandro Ambrosi and Maura Digito and Giovanni Esposito and Antonella Bertola and M. Fabris and Valentina Nofrate and Enzo Mammano and Alberta Leon and Donato Nitti and Mario Lise},
  journal={International journal of cancer},
  year={2005},
  volume={115 2},
  pages={256-62}
}
Metastatic spread to the liver is the major contributor to mortality in patients with colorectal carcinoma (CRC). In order to seek for gene expression patterns associated with metastatic potential in primary CRC, we compared the transcriptional profiles of 10 radically resected primary CRCs from patients who did not develop distant metastases within a 5-year follow-up period with those of 10 primary/metastatic tumor pairs from patients with synchronous liver metastases. To focus selectively on… CONTINUE READING

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