Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q.

@article{AlMulla2006MetastaticRO,
  title={Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q.},
  author={Fahd R Al-Mulla and Suad Alfadhli and Ali Al-Hakim and James J. Going and Milad S. Bitar},
  journal={Journal of clinical pathology},
  year={2006},
  volume={59 6},
  pages={624-30}
}
OBJECTIVE To investigate the prognostic value for loss of heterozygosity (LOH) of chromosomes 4 and 14q in early-stage colorectal cancer (CRC). METHODS A total of 70, largely microsatellite stable, tumours and their corresponding normal mucosa were subjected to microdissection and analysed for LOH at chromosomes 4 and 14q by using 13 highly polymorphic microsatellite markers. LOH was correlated with the survival of the patients, using univariate, multivariate and Kaplan-Meier's survival… CONTINUE READING

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