Metastatic potential correlates with enzymatic degradation of basement membrane collagen

@article{Liotta1980MetastaticPC,
  title={Metastatic potential correlates with enzymatic degradation of basement membrane collagen},
  author={L. Liotta and K. Tryggvason and S. Garbisa and I. Hart and C. Foltz and S. Shafie},
  journal={Nature},
  year={1980},
  volume={284},
  pages={67-68}
}
Tumour cells traverse epithelial and endothelial basement membranes during the successive stages of the metastatic process. At the transition from in situ to invasive carcinoma, local dissolution of the basement membrane is observed microscopically1,2, and coincides with tumour cell invasion of the underlying stroma. Tumour cells further traverse the endothelial basement membrane during entry into and egress from blood vessels3–5. Electron microscopic studies have shown local dissolution of… Expand
Type IV collagenases in tumor invasion and metastasis
Role of collagenases in tumor cell invasion
Basement membranes in cancer.
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