Metastatic outgrowth encompasses COL-I, FN1 and POSTN upregulation and assembly to fibrillar networks regulating cell adhesion, migration and growth

@inproceedings{Soikkeli2010MetastaticOE,
  title={Metastatic outgrowth encompasses COL-I, FN1 and POSTN upregulation and assembly to fibrillar networks regulating cell adhesion, migration and growth},
  author={Johanna Soikkeli and Meng Di Yin and Erkki H{\"o}ltt{\"a}},
  booktitle={The American journal of pathology},
  year={2010}
}
Although the outgrowth of micrometastases into macrometastases is the rate-limiting step in metastatic progression and the main determinant of cancer fatality, the molecular mechanisms involved have been little studied. Here, we compared the gene expression profiles of melanoma lymph node micro- and macrometastases and unexpectedly found no common up-regulation of any single growth factor/cytokine, except for the cytokine-like SPP1. Importantly, metastatic outgrowth was found to be consistently… CONTINUE READING