Metastatic melanoma moves on: translational science in the era of personalized medicine

@article{Levesque2017MetastaticMM,
  title={Metastatic melanoma moves on: translational science in the era of personalized medicine},
  author={Mitchell P. Levesque and Phil F. Cheng and Marieke I.G. Raaijmakers and Annalisa Saltari and Reinhard Dummer},
  journal={Cancer and Metastasis Reviews},
  year={2017},
  volume={36},
  pages={7-21}
}
Progress in understanding and treating metastatic melanoma is the result of decades of basic and translational research as well as the development of better in vitro tools for modeling the disease. Here, we review the latest therapeutic options for metastatic melanoma and the known genetic and non-genetic mechanisms of resistance to these therapies, as well as the in vitro toolbox that has provided the greatest insights into melanoma progression. These include next-generation sequencing… CONTINUE READING

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