Metastatic cancer stem cells: new molecular targets for cancer therapy.

@article{Leirs2011MetastaticCS,
  title={Metastatic cancer stem cells: new molecular targets for cancer therapy.},
  author={Gustavo Jos{\'e} Leir{\'o}s and Mar{\'i}a Eugenia Bala{\~n}{\'a}},
  journal={Current pharmaceutical biotechnology},
  year={2011},
  volume={12 11},
  pages={1909-22}
}
The cancer stem cell (CSC) hypothesis, predicts that a small subpopulation of cancer cells that possess "stem-like" characteristics, are responsible for initiating and maintaining cancer growth. According to the CSC model the many cell populations found in a tumour might represent diverse stages of differentiation. From the cellular point of view metastasis is considered a highly inefficient process and only a subset of tumour cells is capable of successfully traversing the entire metastatic… CONTINUE READING

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