Metastatic cancer stem cells: an opportunity for improving cancer treatment?

  title={Metastatic cancer stem cells: an opportunity for improving cancer treatment?},
  author={Maximilian Diehn and Ravindra Majeti},
  journal={Cell stem cell},
  volume={6 6},
A growing body of evidence has demonstrated that many human tumors are organized as cellular hierarchies initiated and maintained by a subpopulation of self-renewing cancer stem cells (CSCs) (Dalerba et al., 2007; Jordan et al., 2006). These CSCs have been isolated based on their surface immunophenotypes and the ability to serially transplant human cancer in immunodeficient mice, where they give rise to the heterogeneous cell types comprising the original tumor. Many human cancers, particularly… CONTINUE READING


Publications citing this paper.
Showing 1-7 of 7 citations


Publications referenced by this paper.
Showing 1-2 of 2 references


  • C. T. Jordan, M. L. Guzman, M. Noble
  • Engl. J. Med. 355, 1253–1261. Nagrath, S…
  • 2006
1 Excerpt


  • T. Brabletz, A. Jung, S. Spaderna, F. Hlubek, T. Kirchner
  • Rev. Cancer 5, 744–749. Cunningham, D., Atkin, W…
  • 2005
2 Excerpts