Metastatic ability of MXT mouse mammary subpopulations correlates with clonal expression and/or membrane-association of gelatinase A.

@article{Llorens1997MetastaticAO,
  title={Metastatic ability of MXT mouse mammary subpopulations correlates with clonal expression and/or membrane-association of gelatinase A.},
  author={Ana Mart́ınez Llorens and Ant{\`o}nia Vinyals and Pedro Al{\'i}a and Lluis-A Lopez-Barcons and Milagro Gonzalez-Garrigues and {\'A}ngels Fabra},
  journal={Molecular carcinogenesis},
  year={1997},
  volume={19 1},
  pages={54-66}
}
We have developed a novel murine mammary tumor system with variants representing different stages of tumor progression. The MXT-s parental cell line was established from a urethane-induced and hormone-sensitive mammary tumor. MXT-s parental cells are highly tumorigenic but poorly metastatic. MXT clones and variants were selected by either in vitro or in vivo procedures, and they differ in metastatic ability and 17 beta-estradiol dependency for tumor growth. The MXT-c1.1 and MXT-B2 cell lines… CONTINUE READING

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