Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.

@article{Jacob2015MetastaticCC,
  title={Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.},
  author={L. Jacob and Sakari Vanharanta and A. C. Obenauf and M. Pirun and A. Viale and N. Socci and Joan Massagu{\'e}},
  journal={Cancer research},
  year={2015},
  volume={75 18},
  pages={
          3713-9
        }
}
  • L. Jacob, Sakari Vanharanta, +4 authors Joan Massagué
  • Published 2015
  • Biology, Medicine
  • Cancer research
  • Several experimental models faithfully recapitulate many important facets of human metastatic disease. Here, we have performed whole-exome sequencing in five widely used experimental metastasis models that were independently derived through in vivo selection from heterogeneous human cancer cell lines. In addition to providing an important characterization of these model systems, our study examines the genetic evolution of metastatic phenotypes. We found that in vivo selected highly metastatic… CONTINUE READING
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