Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.

  title={Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.},
  author={L. Jacob and Sakari Vanharanta and A. C. Obenauf and M. Pirun and A. Viale and N. Socci and Joan Massagu{\'e}},
  journal={Cancer research},
  volume={75 18},
  • L. Jacob, Sakari Vanharanta, +4 authors Joan Massagué
  • Published 2015
  • Biology, Medicine
  • Cancer research
  • Several experimental models faithfully recapitulate many important facets of human metastatic disease. Here, we have performed whole-exome sequencing in five widely used experimental metastasis models that were independently derived through in vivo selection from heterogeneous human cancer cell lines. In addition to providing an important characterization of these model systems, our study examines the genetic evolution of metastatic phenotypes. We found that in vivo selected highly metastatic… CONTINUE READING
    36 Citations
    The contributions of cancer cell metabolism to metastasis
    • 26
    • PDF
    Genomic control of metastasis
    Inherent variability of cancer-specific aneuploidy generates metastases
    • 21
    Epigenetic determinants of metastasis
    • 30
    • Highly Influenced
    NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.
    • 13
    • PDF
    Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing
    • 142
    • Highly Influenced
    • PDF
    c-MYC Drives Breast Cancer Metastasis to the Brain, but Promotes Synthetic Lethality with TRAIL
    • 16
    • PDF
    Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context
    • 11
    • PDF


    Comparative lesion sequencing provides insights into tumor evolution
    • 679
    • PDF
    Accumulation of driver and passenger mutations during tumor progression
    • 638
    • PDF
    Origins of metastatic traits.
    • 352
    • PDF
    The clonal evolution of tumor cell populations.
    • 5,693
    Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft
    • 1,085
    • PDF
    Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
    • 1,065
    • PDF
    Modeling metastasis in the mouse
    • 70
    • PDF