Metastatic Behavior of Human Breast Carcinomas Overexpressing the Bcl-xL Gene: A Role in Dormancy and Organospecificity

@article{Rubio2001MetastaticBO,
  title={Metastatic Behavior of Human Breast Carcinomas Overexpressing the Bcl-xL Gene: A Role in Dormancy and Organospecificity},
  author={N{\'u}ria Rubio and Laura Espa{\~n}a and Yolanda Blanco Fern{\'a}ndez and Jer{\'o}nimo Blanco and A. De la Sierra},
  journal={Laboratory Investigation},
  year={2001},
  volume={81},
  pages={725-734}
}
The ability of metastatic cells to survive antiapoptotic signals may contribute to the organospecific-spread patterns of clinical metastasis and dormancy. MDA-MB-435 breast cancer cells (435/Bcl-xL), which overexpress the Bcl-xL gene, were labeled with the luciferase gene and injected orthotopically into homozygous athymic Balb/c (nude) mice to study the metastatic behavior of the breast cancer cells. The overexpression of Bcl-xL in tumors increased the overall metastatic burden in mice (bones… CONTINUE READING

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